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<!DOCTYPE html><html lang="en" style="background-color:#ffffff;margin:0;padding:0"><head> <title>Scholar Rock</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"> <meta name="viewport" content="width=device-width"> <!--[if gte mso 9]><xml><o:OfficeDocumentSettings><o:AllowPNG/><o:PixelsPerInch>96</o:PixelsPerInch></o:OfficeDocumentSettings></xml> <![endif]--> <!--[if (gte mso 15)|(IE)]> <style type="text/css"> table{border-collapse:collapse;border-spacing:0;mso-line-height-rule:exactly;mso-margin-bottom-alt:0;mso-margin-top-alt:0;mso-table-lspace:0pt;mso-table-rspace:0pt;} </style> <![endif]--> <!--[if gte mso 9]> <style>li{margin-left:12px !important;mso-special-format:bullet;} </style> <![endif]--> <!--[if gte mso 9]> <style>sup,sub{font-size:100% !important;} </style> <![endif]--> <style>#outlook a{padding:0;}.ReadMsgBody{width:100%;}body,table,td,a{-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;}table,td{mso-table-lspace:0pt;mso-table-rspace:0pt;}img{-ms-interpolation-mode:bicubic;}body{margin:0;padding:0;}img{border:0;height:auto;line-height:100%;outline:none;text-decoration:none;}table{border-collapse:collapse!important;border-spacing:0!important;}html,body{margin:0 auto!important;padding:0!important;height:100%!important;width:100%!important;}p{margin:0 !important;padding:0!important;}u+.body .listGmail{margin-left:20px!important;} @media (max-width:640px){u+.body .listGmail{margin-left:14px!important;}u+.body .listGmail li{padding-left:6px!important;} }.nolink a{color:inherit!important;text-decoration:none!important;font-size:inherit!important;font-family:inherit!important;font-weight:inherit!important;line-height:inherit!important;} </style> </head> <body width="100%" style="margin:0;color:#000000;font-family:Arial,Helvetica,Verdana,sans-serif;font-size:16px;line-height:22px;mso-line-height-rule:exactly;-webkit-font-smoothing:antialiased;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;background-color:#ffffff;padding:0;height:100%;width:100%"><center style="width:100%"><div style="display:none;width:0;height:0;max-height:0;line-height:0;mso-hide:all;overflow:hidden;visibility:hidden;padding:0;margin:0;font-size:1px;color:#ffffff; line-height:1px;opacity:0"> Helpful resources to support treatment access. ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#196162;padding-left:20px;padding-right:20px;padding-top:6px;padding-bottom:6px"><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:0;mso-line-height-rule:exactly;font-family:Arial,Helvetica, sans-serif;font-size:14px;line-height:18px;font-weight:700;color:#ffffff"> <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PI.pdf?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=prescribing_information_0418" target="_blank" style="color:#ffffff;text-decoration:underline">Prescribing Information</a></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-left:20px;padding-right:20px;padding-bottom:0;padding-top:12px"><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:20px;"> <a href="https://www.scholarrocksupports.com/hcp/?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=scholar_rock_supports_logo_0418" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/hcp/2026/outlook-hcp-srs-access-resources/scholar-rock-supports-logo.png" width="200" height="44" border="0" alt="Scholar Rock Supports™ logo" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Dear/Hello/Hi/Good morning/Good afternoon/Good evening/Greetings] [Dr/Doctor/Miss/Mr/Mrs/Ms] [First Name] [Last Name]<span style="color:#000000">,</span></div><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0;margin-bottom:32px;mso-line-height-rule:exactly; text-align:left;font-size:14px;line-height:16px;color:#000000"> <span style="color:#FF00FB">[As a follow-up from our conversation,]</span> <span style="color:#000000">I’m sharing a resource that may be helpful in navigating access to ISEMBYLD™ (apitegromab-mstn).</span> <span style="color:#FF00FB">[A member of our Scholar Rock team will follow up with you to answer any questions and discuss this further.]</span></div><div style="box-sizing:border-box;display:block;margin:0; margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Ordering and Distribution Overview</b> <a href="https://www.isembyldhcp.com/ordering-distribution-overview.pdf?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=ordering_distribution_overview_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size: 12px;line-height:16px">How to order, store, and coordinate product delivery and logistics.</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Billing and Coding Guide</b> <a href="https://www.isembyldhcp.com//billing-coding-guide.pdf?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=billing_coding_guide_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px;line-height:16px">Guidance on billing, coding, and claim submission, including documentation requirements for outpatient sites of care.</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Prior Authorization and Appeals Toolkit </b> <a href="https://www.isembyldhcp.com/authorization-appeals-toolkit.pdf?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=authorization_appeals_toolkit_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px;line-height:16px">Step-by-step guidance to help prepare, submit, and follow up on prior authorization requests and appeals.</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Letter of Medical Necessity Template (Initiating Treatment)</b> <a href="https://www.isembyldhcp.com/letter-of-medical-necessity-initiating.docx?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=medical_necessity_initiating_0418" target="_blank" style="color:#196162;text-decoration:none; border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px;line-height:16px">Template to help support initial coverage or prior authorization requests.</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Letter of Medical Necessity Template (Continuing Treatment)</b> <a href="https://www.isembyldhcp.com/letter-of-medical-necessity-continuing.docx?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=medical_necessity_continuing_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px;line-height:16px">Template to help support reauthorization or continued coverage requests.</span></div><div style="box-sizing:border-box;display:block;margin: 0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Letter of Appeal Template for Healthcare Providers</b> <a href="https://www.isembyldhcp.com/appeal-letter-hcp.docx?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=appeal_letter_hcp_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px; line-height:16px">Template to help providers respond to a coverage denial and submit an appeal with supporting information.</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:16px;color:#000000">See <b>Letter of Appeal Template for Patients and Caregivers</b> <a href="https://www.isembyldhcp.com/appeal-letter-patient.docx?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=appeal_letter_patient_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">here</a><br><span style="font-size:12px;line-height:16px">Template to help patients or caregivers provide a supporting statement describing personal experience for inclusion in a provider-submitted appeal after a denial.</span></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-left:20px;padding-right:20px;padding-bottom:24px;padding-top:8px"><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0;margin-bottom:16px;mso-line-height-rule: exactly;text-align:left;font-size:14px;line-height:18px;color:#000000"> If you have any questions about the information shared or need additional support, please don’t hesitate to reach out. </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB">[Sincerely] [Best] [Regards]<span style="color:#000000">,</span></div><div style="box-sizing:border-box; display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB">[Scholar Rock Field Team Member first name and last name]</div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB">[Scholar Rock Field Team Member title]</div><div style="box-sizing:border-box; display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB">[Scholar Rock Field Team Member phone number]</div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:32px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB">[Scholar Rock Field Team Member email address]</div> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td align="left" style="border-top:2px solid #dfdfdf;padding-top:28px;"><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0;margin-bottom:16px;mso-line-height-rule:exactly;text-align:left;font-size:14px;line-height:18px;color:#000000"> Visit official <a href="https://www.isembyldhcp.com/?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=isembyld_hcp_0418" target="_blank" style="color:#196162;text-decoration:none;border-bottom:1px solid #196162;font-weight:bold">ISEMBYLD</a> website for more information. </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0 auto;margin-bottom:0px;"> <a href="https://www.isembyldhcp.com/?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=isembyld_logo_0418" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/hcp/2026/outlook-hcp-srs-access-resources/logo-isembyld.png" width="120" height="36" border="0" alt="ISEMBYLD brand logo" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a></div> </td></tr></tbody></table> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="left" style="box-sizing:border-box;background-color:#196162;padding-bottom:24px;padding-left:20px;padding-right:20px;padding-top:24px"><div style="box-sizing:border-box;text-align:left;display:block;margin:0 auto;margin-bottom:12px;"> <a href="https://scholarrock.com/?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=scholar_rock_logo_0418" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/hcp/2026/outlook-hcp-srs-access-resources/footer-logo-scholar-rock.png" width="194" height="48" border="0" alt="Scholar Rock corporate logo" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a></div><div style="box-sizing: border-box;text-align:left;display:block;margin:0;margin-bottom:20px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <a href="https://scholarrock.com/contact-us/?utm_source=hcp_outlook&utm_medium=email&utm_campaign=hcp_branded&utm_content=contact_us_footer_0418" target="_blank" style="color:#ffffff;text-decoration:none;">Contact Us</a> <a href="https://scholarrock.com/privacy-policy/" target="_blank" style="color:#ffffff;text-decoration:none;">Privacy Policy</a></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <span class="nolink">301 Binney Street, 3rd Floor<br> Cambridge, MA 02142</span></div><div style="box-sizing:border-box; text-align:left;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <span class="nolink">ISEMBYLD and Scholar Rock Supports are trademarks of Scholar Rock.<br> Scholar Rock © 2026. All rights reserved.<br> US-APIT-0418 09/26</span></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:0;font-family:Arial,Helvetica, Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> This advertisement is intended only for healthcare professionals and payers in the United States.<br> Reply with "unsubscribe" to be removed from future ISEMBYLD Marketing communications. </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table></center> </body></html>