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<!DOCTYPE html><html lang="en" style="background-color:#ffffff;margin:0;padding:0"><head> <title>Scholar Rock</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"> <meta name="viewport" content="width=device-width"> <!--[if gte mso 9]><xml><o:OfficeDocumentSettings><o:AllowPNG/><o:PixelsPerInch>96</o:PixelsPerInch></o:OfficeDocumentSettings></xml> <![endif]--> <!--[if (gte mso 15)|(IE)]> <style type="text/css"> table{border-collapse:collapse;border-spacing:0;mso-line-height-rule:exactly;mso-margin-bottom-alt:0;mso-margin-top-alt:0;mso-table-lspace:0pt;mso-table-rspace:0pt;} </style> <![endif]--> <!--[if gte mso 9]> <style>li{margin-left:12px !important;mso-special-format:bullet;} </style> <![endif]--> <!--[if gte mso 9]> <style>sup,sub{font-size:100% !important;} </style> <![endif]--> <style>#outlook a{padding:0;}.ReadMsgBody{width:100%;}body,table,td,a{-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;}table,td{mso-table-lspace:0pt;mso-table-rspace:0pt;}img{-ms-interpolation-mode:bicubic;}body{margin:0;padding:0;}img{border:0;height:auto;line-height:100%;outline:none;text-decoration:none;}table{border-collapse:collapse!important;border-spacing:0!important;}html,body{margin:0 auto!important;padding:0!important;height:100%!important;width:100%!important;}p{margin:0 !important;padding:0!important;}u+.body .listGmail{margin-left:20px!important;} @media (max-width:640px){u+.body .listGmail{margin-left:14px!important;}u+.body .listGmail li{padding-left:6px!important;} }.nolink a{color:inherit!important;text-decoration:none!important;font-size:inherit!important;font-family:inherit!important;font-weight:inherit!important;line-height:inherit!important;} </style> </head> <body width="100%" style="margin:0;color:#000000;font-family:Arial,Helvetica,Verdana,sans-serif;font-size:16px;line-height:22px;mso-line-height-rule:exactly;-webkit-font-smoothing:antialiased;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;background-color:#ffffff;padding:0;height:100%;width:100%"><center style="width:100%"><div style="display:none;width:0;height:0;max-height:0;line-height:0;mso-hide:all;overflow:hidden;visibility:hidden;padding:0;margin:0;font-size:1px;color:#ffffff; line-height:1px;opacity:0"> Helpful resources from your ROCC about treatment ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#00205B;padding-left:20px;padding-right:20px;padding-top:6px;padding-bottom:6px"><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:0;mso-line-height-rule:exactly;font-family:Arial,Helvetica, sans-serif;font-size:14px;line-height:18px;font-weight:700;color:#ffffff"> <a href="https://www.isembyld.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=isi_0394#isi" target="_blank" style="color:#ffffff;text-decoration:underline">Safety Information</a> | <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PI.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=prescribing_information_header_0394" target="_blank" style="color:#ffffff;text-decoration:underline">Prescribing Information</a> | <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PatientInfo.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=patient_information_header_0394" target="_blank" style="color:#ffffff;text-decoration:underline">Patient Information</a></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:8px;padding-top:8px"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:center;font-size:18px;line-height:22px;font-weight:700;color: #12A166">Introducing ISEMBYLD™ (apitegromab-mstn), the first and only FDA-approved muscle-targeted treatment for SMA. It is designed to improve motor function in adults and children ages 2 years and older receiving an SMN2-targeted treatment.</div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:8px;padding-top:8px"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight: 400;color:#FF00FB"> [Dear/Hello/Hi/Good morning/Good afternoon/Good evening/Greetings] [Miss/Mr/Mrs/Ms/blank] [First Name] [Last Name]<span style="color:#000000">,</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Hi [Name], I'm your Rx Onboarding and Care Coordinator (ROCC), and I wanted to share some information about ISEMBYLD with you. I’d also love to find a time to connect so we can walk through the materials together and talk through any questions you may have. / Hi [Name], ahead of our conversation, I wanted to send along some information about ISEMBYLD for you to review. / It was great speaking with you recently. I’m sharing the ISEMBYLD materials we talked about on our call. / Hi [Name], it’s been a while since we connected. I wanted to send along some helpful resources about ISEMBYLD that may be useful to you.] </div><div style="font-family:Arial,Helvetica,sans-serif;color:#000000;box-sizing:border-box;display:block;margin:0;margin-bottom:8px;mso-line-height-rule:exactly;text-align:left;font-size:14px;line-height:18px"> ISEMBYLD is a prescription medicine used to treat spinal muscular atrophy (SMA) in adults and children 2 years of age and older who are currently receiving a survival motor neuron 2 (SMN2)-targeted treatment. Below are some resources that may be helpful as you learn more about ISEMBYLD and what to expect. </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:0;padding-top:0"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:20px;color:#00205B">Please see <b>ISEMBYLD Patient Brochure <a href="https://www.isembyld.com/isembyld-patient-brochure.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=core_pt_product_brochure_0394" target="_blank" style="color:#12A166;text-decoration:underline">here</a></b></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:20px;color:#00205B">Please see <b>ISEMBYLD Patient Infusion Journal <a href="https://www.isembyld.com/isembyld-patient-infusion-journal.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=patient_infustion_journal_0394" target="_blank" style="color:#12A166;text-decoration:underline">here</a></b></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:20px;color:#00205B">Please see <b>Scholar Rock Supports™ Brochure <a href="https://www.scholarrocksupports.com/scholar-rock-supports-brochure.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=scholar_rock_supports_brochure_0394" target="_blank" style="color:#12A166;text-decoration:underline">here</a></b></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:20px;color:#00205B">Please see <b>ISEMBYLD Infusion Day Brochure <a href="https://www.isembyld.com/isembyld-patient-infusion-brochure.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=infusion_day_brochure_0394" target="_blank" style="color:#12A166;text-decoration:underline">here</a></b></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:20px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:16px;line-height:20px;color:#00205B">Please see <b>Sample Letter of Appeal for Insurance Coverage of ISEMBYLD <a href="https://www.isembyld.com/appeal-letter-patient.docx?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=appeal_letter_patient_0394" target="_blank" style="color:#12A166;text-decoration:underline">here</a></b></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:0;padding-top:8px"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight: 400;color:#FF00FB"> [The next step is to meet with me, your ROCC. Here are a few times that might work: [XXMonth][XXDay][XXYear] @ [X:XXTime][AM/PM], [XXMonth][XXDay][XXYear] @ [X:XXTime][AM/PM], [XXMonth][XXDay][XXYear] @ [X:XXTime][AM/PM]. If you prefer a different time, please let me know your availability. / I look forward to connecting with you soon. Please reach out with any questions in the meantime. / Please know that as your ROCC, I’m here to help you—every step of the way. And I’ll be checking in at every stage of your journey. If you have any questions, don't hesitate to reach out. / As your ROCC, I’m here to answer your questions and help. Do you need additional info about ISEMBYLD or any assistance getting started? Please let me know if you’d like to meet online—I'm available to help in any way that works for you.] </div><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0; margin-bottom:0;mso-line-height-rule:exactly;text-align:left;font-size:10px;line-height:12px;color:#00205B"> FDA=US Food and Drug Administration; ROCC=Rx Onboarding and Care Coordinator; SMA=spinal muscular atrophy; SMN2=survival motor neuron 2. </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0" align="center" style="margin:0 auto;"><tr><td width="600"> <![endif]--> <table width="100%" border="0" cellpadding="0" cellspacing="0" style="max-width:600px;box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="left" style="box-sizing:border-box;vertical-align:top;background-color:#ffffff;padding-left:20px;padding-right:20px;padding-bottom:12px;padding-top:12px" valign="top"><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica, Verdana,sans-serif;font-weight:bold;font-size:14px;line-height:16px;color:#00205B"> What is ISEMBYLD (apitegromab-mstn)? </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B"> ISEMBYLD is a prescription medicine used to treat spinal muscular atrophy (SMA) in adults and children 2 years of age and older who are currently receiving a survival motor neuron 2 <span style="white-space:nowrap;">(SMN2)‑targeted</span> treatment. </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:bold;font-size:14px;line-height:16px;color:#00205B"> IMPORTANT SAFETY INFORMATION </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:bold;font-size: 14px;line-height:16px;color:#00205B"> Before taking ISEMBYLD, tell your healthcare provider about all of your medical conditions, including if you: </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td width="8" style="width:8px;"> </td><td width="12" style="width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">have a history of low bone density or bone fractures </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">are pregnant or plan to become pregnant. If you are pregnant or are planning to become pregnant, ask your healthcare provider for advice before taking this medicine. It is not known if ISEMBYLD will harm your unborn baby. Tell your healthcare provider right away if you become pregnant during treatment with ISEMBYLD </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:8px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">are breastfeeding or plan to breastfeed. It is not known if ISEMBYLD passes into breast milk. Talk to your healthcare provider about the best way to feed your baby while on treatment with ISEMBYLD </td></tr></tbody></table><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B"> <b>Tell your healthcare provider about all the medicines you take,</b> including prescription and over-the-counter medicines, vitamins, and herbal supplements. Keep a list of them to show your healthcare provider, including your pharmacist, when you get a new medicine. </div> <div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:bold;font-size:14px;line-height:16px;color:#00205B"> What are the possible side effects of ISEMBYLD? </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:8px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top"><b>Fractures.</b> Treatment with ISEMBYLD may increase the risk of bone fractures, including serious fractures. Bone fractures may happen with or without a fall or other injury. Your healthcare provider may consider stopping treatment with ISEMBYLD if you experience a bone fracture during treatment </td></tr></tbody></table><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B"> <b>The most common side effects of ISEMBYLD</b> include: </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">upper respiratory tract infections </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">vomiting </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">cough </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">viral infections </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">headache </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">stomach flu (gastroenteritis) </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:4px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:4px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">sore throat (pharyngitis) </td></tr><tr><td width="8" style="width:8px;"> </td><td width="12" style="padding-bottom:8px;width:12px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">• </td><td style="padding-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B" align="left" valign="top">hypersensitivity </td></tr></tbody></table><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif;font-weight:normal;font-size:14px;line-height:16px;color:#00205B"> These are not all of the possible side effects of ISEMBYLD. Call your healthcare provider for medical advice about side effects. </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica,Verdana,sans-serif; font-weight:bold;font-size:14px;line-height:16px;color:#00205B"> You are encouraged to report negative side effects of prescription drugs to the FDA. Visit <a href="https://www.fda.gov/medwatch" target="_blank" style="text-decoration:underline;color:#00205B">http://www.fda.gov/medwatch</a> or call <span class="nolink" style="white-space:nowrap">1-800-FDA-1088</span>. </div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:8px;font-family:Arial,Helvetica, Verdana,sans-serif;font-weight:bold;font-size:14px;line-height:16px;color:#00205B"> Please see full <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PI.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=prescribing_information_body_0394" target="_blank" style="text-decoration:underline;color:#00205B">Prescribing Information</a> and <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PatientInfo.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=patient_information_body_0394" target="_blank" style="text-decoration:underline;color:#00205B">Patient Information</a>. </div> </td></tr></tbody></table> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:0;padding-top:0"><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:8px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400; color:#FF00FB"> [Sincerely] [Best] [Regards]<span style="color:#000000">,</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [ROCC first name and last name] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400; color:#FF00FB"> [ROCC title] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [ROCC email address] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [ROCC phone number] </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td width="20" style="width:20px;background-color:#ffffff"> </td><td align="center" style="box-sizing:border-box;background-color:#12A166;padding:20px"> <img src="https://cdn.scholarrockcommunications.com/campaigns/branded/patient/2026/outlook-modular-email/scholar-rock-supports-logo.png" width="180" height="48" border="0" alt="Visit the Scholar Rock Supports website for assistance and resources" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"><div style="box-sizing:border-box;display:block;margin:0; margin-bottom:0;height:16px;line-height:16px;mso-line-height-rule:exactly;background-color:transparent;text-align:left"> </div><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0;margin-bottom:0;mso-line-height-rule:exactly;text-align:center;font-size:18px;line-height:24px;font-weight:700;color:#ffffff"> Visit <a href="https://www.scholarrocksupports.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=scholar_rock_supports_0394" target="_blank" style="color:#ffffff;text-decoration:none;border-bottom:2px solid #ffffff;">Scholar Rock Supports website</a> for assistance and resources </div> </td><td width="20" style="width:20px;background-color:#ffffff"> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-bottom:16px;padding-top:16px"><div style="font-family:Arial,Helvetica,sans-serif;box-sizing:border-box;display:block;margin:0;margin-bottom:24px;mso-line-height-rule:exactly;text-align:center;font-size: 14px;line-height:18px;font-weight:700;color:#12A166"> <a href="https://www.isembyld.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=isembyld_0394" target="_blank" style="text-decoration:none;border-bottom:1px solid #12A166;color:#12A166">Click here for official ISEMBYLD website</a></div> <a href="https://www.isembyld.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=isembyld_logo_0394" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/patient/2026/outlook-modular-email/isembyld-logo.png" width="160" height="50" border="0" alt="Visit the official ISEMBYLD website" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="left" style="box-sizing:border-box;background-color:#00205B;padding-bottom:24px;padding-left:20px;padding-right:20px;padding-top:24px"><div style="box-sizing:border-box;text-align:left;display:block;margin:0 auto;margin-bottom:16px;"> <a href="https://scholarrock.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=scholar_rock_logo_0394" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/patient/2026/outlook-modular-email/footer-scholar-rock-logo.png" width="100" height="50" border="0" alt="Scholar Rock" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a></div><div style="box-sizing:border-box;text-align:left; display:block;margin:0;margin-bottom:20px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <a href="https://scholarrock.com/contact-us/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=contact_us_footer_0394" target="_blank" style="color:#ffffff;text-decoration:none;border-bottom:1px solid #ffffff;">Contact Us</a> <a href="https://scholarrock.com/privacy-policy/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=privacy_policy_footer_0394" target="_blank" style="color:#ffffff;text-decoration:none;border-bottom:1px solid #ffffff;">Privacy Policy</a></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly; font-weight:normal;"> <span class="nolink">301 Binney Street, 3rd Floor<br> Cambridge, MA 02142</span></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <span class="nolink">ISEMBYLD and Scholar Rock Supports are trademarks of Scholar Rock.<br> Scholar Rock © 2026. All rights reserved.<br> US-APIT-0394 10/26</span></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:0;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> This is an advertisement.<br> Reply with "unsubscribe" to be removed from future ISEMBYLD Marketing communications. </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table></center> </body></html>