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<!DOCTYPE html><html lang="en" style="background-color:#ffffff;margin:0;padding:0"><head> <title>Scholar Rock</title> <meta http-equiv="Content-Type" content="text/html; charset=UTF-8"> <meta name="viewport" content="width=device-width"> <!--[if gte mso 9]><xml><o:OfficeDocumentSettings><o:AllowPNG/><o:PixelsPerInch>96</o:PixelsPerInch></o:OfficeDocumentSettings></xml> <![endif]--> <!--[if (gte mso 15)|(IE)]> <style type="text/css"> table{border-collapse:collapse;border-spacing:0;mso-line-height-rule:exactly;mso-margin-bottom-alt:0;mso-margin-top-alt:0;mso-table-lspace:0pt;mso-table-rspace:0pt;} </style> <![endif]--> <!--[if gte mso 9]> <style>li{margin-left:12px !important;mso-special-format:bullet;} </style> <![endif]--> <!--[if gte mso 9]> <style>sup,sub{font-size:100% !important;} </style> <![endif]--> <style>#outlook a{padding:0;}.ReadMsgBody{width:100%;}body,table,td,a{-webkit-text-size-adjust:100%;-ms-text-size-adjust:100%;}table,td{mso-table-lspace:0pt;mso-table-rspace:0pt;}img{-ms-interpolation-mode:bicubic;}body{margin:0;padding:0;}img{border:0;height:auto;line-height:100%;outline:none;text-decoration:none;}table{border-collapse:collapse!important;border-spacing:0!important;}html,body{margin:0 auto!important;padding:0!important;height:100%!important;width:100%!important;}p{margin:0 !important;padding:0!important;}u+.body .listGmail{margin-left:20px!important;} @media (max-width:640px){u+.body .listGmail{margin-left:14px!important;}u+.body .listGmail li{padding-left:6px!important;} }.nolink a{color:inherit!important;text-decoration:none!important;font-size:inherit!important;font-family:inherit!important;font-weight:inherit!important;line-height:inherit!important;} </style> </head> <body width="100%" style="margin:0;color:#000000;font-family:Arial,Helvetica,Verdana,sans-serif;font-size:16px;line-height:22px;mso-line-height-rule:exactly;-webkit-font-smoothing:antialiased;-ms-text-size-adjust:100%;-webkit-text-size-adjust:100%;background-color:#ffffff;padding:0;height:100%;width:100%"><center style="width:100%"><div style="display:none;width:0;height:0;max-height:0;line-height:0;mso-hide:all;overflow:hidden;visibility:hidden;padding:0;margin:0;font-size:1px;color:#ffffff; line-height:1px;opacity:0"> Welcome to Scholar Rock Supports™. ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ </div> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#196162;padding-left:20px;padding-right:20px;padding-top:6px;padding-bottom:6px"><div style="box-sizing:border-box;text-align:center;display:block;margin:0;margin-bottom:0;mso-line-height-rule:exactly;font-family:Arial,Helvetica, sans-serif;font-size:14px;line-height:18px;font-weight:700;color:#ffffff"> <a href="https://scholarrock.com/documents/label/us/ISEMBYLD_PI.pdf?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=prescribing_information_header_0416" target="_blank" style="color:#ffffff;text-decoration:underline">Prescribing Information</a></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> </td></tr><tr><td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-left:20px;padding-right:20px;padding-bottom:8px;padding-top:28px"> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td align="left" valign="top" style="padding-bottom:24px;text-align:left"><a href="https://www.scholarrocksupports.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=scholar_rock_supports_logo_0416" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/patient/2026/outlook-patient-srs-eap-email/scholar-rock-supports-logo.png" width="200" height="44" border="0" alt="Scholar Rock Supports™ logo" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a> </td></tr><tr><td align="left" valign="top" style="padding-bottom:12px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">Dear <span style="color:#FF00FB">[Patient/Caregiver Name]</span>, </td></tr><tr><td align="left" valign="top" style="padding-bottom:12px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">Thank you for your continued participation in the apitegromab Expanded Access Program (EAP). Your commitment has helped advance care for people living with spinal muscular atrophy (SMA), and we’re honored to have been part of your journey thus far. </td></tr><tr><td align="left" valign="top" style="padding-bottom:24px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">We’re excited to share that, as of <span style="color:#FF00FB">[date]</span>, apitegromab has been approved by the US Food and Drug Administration (FDA) with the brand name ISEMBYLD™ (apitegromab-mstn). Participants who wish to continue treatment will need to transition to commercial medicine (that is, receive their infusions outside the context of the EAP) when the medicine becomes available. </td></tr><tr><td align="left" valign="top" style="padding-bottom:12px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:700;color:#000000">The Transition Process </td></tr><tr><td align="left" valign="top" style="padding-bottom:24px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">Individuals who wish to continue on ISEMBYLD now that it’s available beyond the EAP should work with their healthcare team on a treatment plan. We understand that patients will require insurance approval before they can transition to ISEMBYLD. Our priority is avoiding interruptions in care, and Scholar Rock is committed to supporting EAP sites, patients, and families before, during, and after transition to help ensure seamless continuity of treatment with ISEMBYLD. </td></tr><tr><td align="left" valign="top" style="padding-bottom:12px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:700;color:#000000">Welcome to Scholar Rock Supports </td></tr><tr><td align="left" valign="top" style="padding-bottom:4px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">A dedicated team at Scholar Rock is here to help make your transition as smooth as possible. As your RX Onboarding and Care Coordinator (ROCC), I'll be reaching out with regular updates about coverage, affordability, and what comes next as you continue treatment. </td></tr></tbody></table> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> </td></tr><tr><td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%" role="none"><tbody><tr><td align="center" bgcolor="#ffffff" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;background-color:#ffffff;padding:20px;padding-left:20px;padding-right:20px;padding-top:4px"> <table border="0" cellpadding="0" cellspacing="0" width="100%" role="none"><tbody><tr><td align="left" valign="top" style="padding-bottom:16px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;color:#000000">Scholar Rock is committed to helping maintain uninterrupted care. If there are any questions you may have, please reach out to me directly at <span style="color:#FF00FB">[xxx-xxx-xxxx and/or FLast@scholarrock.com]</span>. </td></tr></tbody></table><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Sincerely] [Best] [Regards]<span style="color:#000000">,</span></div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Rx Onboarding and Care Coordinator first name and last name] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Rx Onboarding and Care Coordinator title] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:2px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Rx Onboarding and Care Coordinator phone number] </div><div style="box-sizing:border-box;display:block;margin:0;margin-bottom:12px;text-align:left;font-family:Arial,Helvetica,sans-serif;font-size:14px;line-height:18px;font-weight:400;color:#FF00FB"> [Rx Onboarding and Care Coordinator email address] </div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> </td></tr><tr><td align="center"> <table border="0" cellpadding="0" cellspacing="0" width="100%" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;width:100%;" role="none"><tbody><tr><td align="center" style="box-sizing:border-box;font-family:Arial,Helvetica,Verdana,sans-serif;vertical-align:top;background-color:#ffffff" valign="top"> <!--[if mso]> <table border="0" cellpadding="0" cellspacing="0"><tr><td width="600"> <![endif]--><div style="max-width:600px;margin:0 auto;"> <table align="center" width="100%" border="0" cellpadding="0" cellspacing="0" style="box-sizing:border-box;border-collapse:separate!important;mso-table-lspace:0pt;mso-table-rspace:0pt;" role="none"><tbody><tr><td align="left" style="box-sizing:border-box;background-color:#196162;padding-bottom:40px;padding-left:20px;padding-right:20px;padding-top:24px"><div style="box-sizing:border-box;text-align:left;display:block;margin:0 auto;margin-bottom:12px;"> <a href="https://scholarrock.com/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=scholar_rock_logo_0416" target="_blank"><img src="https://cdn.scholarrockcommunications.com/campaigns/branded/patient/2026/outlook-patient-srs-eap-email/logo-scholar-rock.png" width="100" height="50" border="0" alt="" style="max-width:100%;vertical-align:middle;-ms-interpolation-mode:bicubic;display:inline-block"></a></div><div style="box-sizing:border-box;text-align:left;display:block; margin:0;margin-bottom:20px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <a href="https://scholarrock.com/contact-us/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=contact_us_footer_0416" target="_blank" style="color:#ffffff;text-decoration:none;">Contact Us</a> <a href="https://scholarrock.com/privacy-policy/?utm_source=patient_outlook&utm_medium=email&utm_campaign=pt_branded&utm_content=privacy_policy_footer_0416" target="_blank" style="color:#ffffff;text-decoration:none;">Privacy Policy</a></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:12px;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <span class="nolink">301 Binney Street, 3rd Floor<br> Cambridge, MA 02142</span></div><div style="box-sizing:border-box;text-align:left;display:block;margin:0;margin-bottom:0;font-family:Arial,Helvetica,Verdana,sans-serif;color:#ffffff;font-size:10px;line-height:12px;mso-line-height-rule:exactly;font-weight:normal;"> <span class="nolink">ISEMBYLD and Scholar Rock Supports are trademarks of Scholar Rock.<br> Scholar Rock © 2026. All rights reserved.<br> US-APIT-0416 07/26</span></div> </td></tr></tbody></table></div> <!--[if mso]> </td></tr></table> <![endif]--> </td></tr></tbody></table> </td></tr></tbody></table></center> </body></html>